NGS solutions designed for reproducibility, customization, and confidence.
One foundation for all your sequencing needs
Engineered Accuracy
NGS solutions that deliver precise, uniform, and reliable results; every sample, every time.
Built-In Flexibility
Workflows that adapt to your samples, depth, and throughput without compromise.
Enablement at Every Step
Comprehensive tools and hands-on support that simplify adoption, validation, and scaling.
NEW
Introducing the Twist TrueAmp and PCR-Free WGS Library Preparation Kits
Power your sequencing with Twist’s enzyme driven library prep; engineered to deliver more data from your sample, in any workflow.
One foundation for all your sequencing needs
Engineered Accuracy
NGS solutions that deliver precise, uniform, and reliable results; every sample, every time.
Built-In Flexibility
Workflows that adapt to your samples, depth, and throughput without compromise.
Enablement at Every Step
Comprehensive tools and hands-on support that simplify adoption, validation, and scaling.
NEW
Introducing the Twist TrueAmp and PCR-Free WGS Library Preparation Kits
Power your sequencing with Twist’s enzyme driven library prep; engineered to deliver more data from your sample, in any workflow.
Build your Workflow on Confidence
Whether you’re profiling variants, expression levels, or regulatory markers, you need workflows that deliver reliable accuracy and the flexibility to evolve with your goals. Twist provides a unified library prep and enrichment foundation built to support genomics, transcriptomics, and epigenomics.
Genomics
Precision-driven whole genomes, exomes, and targeted panels; Twist delivers engineered accuracy with uniform coverage, low bias, and reliable variant calling. With Twist, you get flexible tools for your evolving genomic needs.
Transcriptomics
Expression confidence from start to signal; Twist delivers exon-aware performance that preserves isoforms and splice junctions. Whether you're profiling bulk RNA or targeted signatures, our modular designs provide the support your workflow needs.
Epigenomics
Epigenomic assays demand sensitivity and precision, and Twist delivers engineered accuracy for this. Custom methylation panels target CpG islands, enhancers, promoters, or cell specific signatures with exceptional uniformity driving consistent results.
Build your Workflow on Confidence
Whether you’re profiling variants, expression levels, or regulatory markers, you need workflows that deliver reliable accuracy and the flexibility to evolve with your goals. Twist provides a unified library prep and enrichment foundation built to support genomics, transcriptomics, and epigenomics.
Genomics
Precision-driven whole genomes, exomes, and targeted panels; Twist delivers engineered accuracy with uniform coverage, low bias, and reliable variant calling. With Twist, you get flexible tools for your evolving genomic needs.
Transcriptomics
Expression confidence from start to signal; Twist delivers exon-aware performance that preserves isoforms and splice junctions. Whether you're profiling bulk RNA or targeted signatures, our modular designs provide the support your workflow needs.
Epigenomics
Epigenomic assays demand sensitivity and precision, and Twist delivers engineered accuracy for this. Custom methylation panels target CpG islands, enhancers, promoters, or cell specific signatures with exceptional uniformity driving consistent results.
NGS Workflows
-
Genomics
Empowering researchers to identify genetic variation and mechanisms
-
Transcriptomics
Enabling researchers to understand how genes are actively expressed
-
Epigenomics
Providing the tools researchers need to explore gene regulation
From low-pass exploration to deep coverage precision, Twist empowers researchers to execute and scale whole genome sequencing with accuracy they can trust.
NGS Optimized Enzymes
Twist’s library prep kits use AI/ML-engineered proprietary enzymes to deliver purpose-built, reliable, and consistently superior NGS results.
Superior Performance for High Quality Data
Get more insights with Twist’s high-yield, high-complexity libraries that boost depth, cut duplicates, and improve coverage.
Flexible Workflows for Any Application
With a full range of tailored library prep kits and adapters, Twist ensures you get the data you need.
With a WES solution built on intelligently designed exome panels and optimized enrichment, Twist delivers highly uniform, on-target coverage of clinically relevant coding and noncoding regions.
Efficient by Design
Twist exome panels focus sequencing on clinically relevant regions, improving efficiency while reducing sequencing and analysis costs.
Better Probes, Better Panels
All Twist panels use dsDNA probes engineered for consistent hybridization and uniform coverage across diverse samples.
Endlessly Adaptable
Twist Exome spike-ins boost coverage of disease-specific or custom targets, enhancing depth and performance without disrupting your workflow.
Twist’s custom DNA enrichment panels deliver tailored, high precision solutions, with expert bioinformatics support for exceptional performance.
Exceptional, Consistent Performance
High fidelity double stranded DNA probes with NGS based quality control ensures balanced probe representation and minimizes dropout.
Panel Blending
Simplify your genomics workflow by combining two or more panels into a single, cohesive assay; either seamlessly in your own lab or with Twist handling the integration for you.
Scalable
Cover exactly the regions you need in your genomic regions of interest; with designs ranging from as few as 100 probes to well over one million.
Twist RNA-Seq solutions, designed for demanding samples such as low input and FFPE so you can get high quality libraries with high yield in a short workflow so you can get results.
Optimized RNA-Seq for Tough, Low-Input Samples
Twist RNA-Seq workflows generate high-quality, uniform libraries, ensuring reliable transcriptome coverage even with challenging material.
Rapid RNA-Seq That Doesn’t Sacrifice Quality
Twist’s fast-protocol RNA-Seq speeds library prep and turnaround while preserving coverage and data quality.
Comprehensive, fast whole-transcriptome RNA-Seq from any sample
Twist Whole Transcriptome RNA Library Prep delivers unbiased, high-quality libraries from total RNA; including FFPE, degraded, or low input sample.
RNA enrichment panels capture cDNA libraries for NGS, with exon-aware designs that deliver deeper, more informative transcription insights.
RNA Exome Panel: More Targets, Fewer Reads
RNA Exome focuses sequencing on protein coding transcripts to enable sensitive detection of low expressing genes while preserving isoform and junction information.
RNA Fusion Panel: Confidently Enrich RNA Gene Fusions
The Twist RNA Fusion Panel Kit is an RNA based enrichment panel that enables more sensitive and targeted detection of gene fusions than conventional methods.
Custom RNA Panel: Target Exactly What Matters.
Capture transcriptomic data with a customized RNA panel; designed to capture and enrich libraries, to provide you with the transcriptomic insights you need
Twist’s methylation sequencing delivers high quality libraries and targeted panels that preserve DNA integrity and maximize CpG recovery.
High Quality, Low-Damage Libraries
Enzymatic conversion and Twist’s optimized library prep preserve DNA integrity, producing higher complexity libraries and reliable results from challenging, low input samples.
More CpGs, Better Resolution
The workflow supports detection of up to ~15% more CpGs than traditional bisulfite based methods, improving coverage of biologically important regions.
Adaptable for Existing Methyl-Seq Pipelines
Twist’s methylation library workflow fits seamlessly into standard NGS and methyl-seq pipelines without major protocol changes.
Twist’s methylation sequencing delivers high quality libraries and targeted panels that preserve DNA integrity and maximize CpG recovery.
Human Methylome Panel: Broad CpG coverage
Expansive content makes this panel ideal for investigating methylation fractions across applications including cancer metastasis, human development, and functional genomics.
Twist Pan Cancer Methylation Panel
A cancer specific methylation panel, focused on methylation targets relevant to 31 different cancers.
Custom Methylation Panels: Smarter Design, Better Data
Custom DNA methylation panels enable high uniformity capture while preserving native methylation patterns through a four probe design targeting fully methylated, unmethylated, sense, and antisense sequences.
NGS Workflows
-
Genomics
Empowering researchers to identify genetic variation and mechanisms
-
Transcriptomics
Enabling researchers to understand how genes are actively expressed
-
Epigenomics
Providing the tools researchers need to explore gene regulation
From low-pass exploration to deep coverage precision, Twist empowers researchers to execute and scale whole genome sequencing with accuracy they can trust.
NGS Optimized Enzymes
Twist’s library prep kits use AI/ML-engineered proprietary enzymes to deliver purpose-built, reliable, and consistently superior NGS results.
Superior Performance for High Quality Data
Get more insights with Twist’s high-yield, high-complexity libraries that boost depth, cut duplicates, and improve coverage.
Flexible Workflows for Any Application
With a full range of tailored library prep kits and adapters, Twist ensures you get the data you need.
With a WES solution built on intelligently designed exome panels and optimized enrichment, Twist delivers highly uniform, on-target coverage of clinically relevant coding and noncoding regions.
Efficient by Design
Twist exome panels focus sequencing on clinically relevant regions, improving efficiency while reducing sequencing and analysis costs.
Better Probes, Better Panels
All Twist panels use dsDNA probes engineered for consistent hybridization and uniform coverage across diverse samples.
Endlessly Adaptable
Twist Exome spike-ins boost coverage of disease-specific or custom targets, enhancing depth and performance without disrupting your workflow.
Twist’s custom DNA enrichment panels deliver tailored, high precision solutions, with expert bioinformatics support for exceptional performance.
Exceptional, Consistent Performance
High fidelity double stranded DNA probes with NGS based quality control ensures balanced probe representation and minimizes dropout.
Panel Blending
Simplify your genomics workflow by combining two or more panels into a single, cohesive assay; either seamlessly in your own lab or with Twist handling the integration for you.
Scalable
Cover exactly the regions you need in your genomic regions of interest; with designs ranging from as few as 100 probes to well over one million.
Twist RNA-Seq solutions, designed for demanding samples such as low input and FFPE so you can get high quality libraries with high yield in a short workflow so you can get results.
Optimized RNA-Seq for Tough, Low-Input Samples
Twist RNA-Seq workflows generate high-quality, uniform libraries, ensuring reliable transcriptome coverage even with challenging material.
Rapid RNA-Seq That Doesn’t Sacrifice Quality
Twist’s fast-protocol RNA-Seq speeds library prep and turnaround while preserving coverage and data quality.
Comprehensive, fast whole-transcriptome RNA-Seq from any sample
Twist Whole Transcriptome RNA Library Prep delivers unbiased, high-quality libraries from total RNA; including FFPE, degraded, or low input sample.
RNA enrichment panels capture cDNA libraries for NGS, with exon-aware designs that deliver deeper, more informative transcription insights.
RNA Exome Panel: More Targets, Fewer Reads
RNA Exome focuses sequencing on protein coding transcripts to enable sensitive detection of low expressing genes while preserving isoform and junction information.
RNA Fusion Panel: Confidently Enrich RNA Gene Fusions
The Twist RNA Fusion Panel Kit is an RNA based enrichment panel that enables more sensitive and targeted detection of gene fusions than conventional methods.
Custom RNA Panel: Target Exactly What Matters.
Capture transcriptomic data with a customized RNA panel; designed to capture and enrich libraries, to provide you with the transcriptomic insights you need
Twist’s methylation sequencing delivers high quality libraries and targeted panels that preserve DNA integrity and maximize CpG recovery.
High Quality, Low-Damage Libraries
Enzymatic conversion and Twist’s optimized library prep preserve DNA integrity, producing higher complexity libraries and reliable results from challenging, low input samples.
More CpGs, Better Resolution
The workflow supports detection of up to ~15% more CpGs than traditional bisulfite based methods, improving coverage of biologically important regions.
Adaptable for Existing Methyl-Seq Pipelines
Twist’s methylation library workflow fits seamlessly into standard NGS and methyl-seq pipelines without major protocol changes.
Twist’s methylation sequencing delivers high quality libraries and targeted panels that preserve DNA integrity and maximize CpG recovery.
Human Methylome Panel: Broad CpG coverage
Expansive content makes this panel ideal for investigating methylation fractions across applications including cancer metastasis, human development, and functional genomics.
Twist Pan Cancer Methylation Panel
A cancer specific methylation panel, focused on methylation targets relevant to 31 different cancers.
Custom Methylation Panels: Smarter Design, Better Data
Custom DNA methylation panels enable high uniformity capture while preserving native methylation patterns through a four probe design targeting fully methylated, unmethylated, sense, and antisense sequences.
