Confidence When Every Read Counts
Confidence in every read separates signal from noise. Missed exons, biased fragments, or uneven coverage can hide critical variants, transcripts, or methylation sites. Twist delivers integrated fragmentation-to-enrichment solutions that maintain consistency and clarity across your entire sequencing workflow
- Focuses sequencing on key regions for meaningful depth.
- Cuts excess sequencing and analysis to lower cost and data load.
- Improves sensitivity for low allele frequency variants.
- Supports tailored panels for specific pathways or research goals.
Why Target with Twist
Target enrichment workflows with Twist deliver scalable, low bias, and highly uniform coverage across large and complex genomic regions; enabling broader discovery, higher sensitivity, and greater flexibility than amplicon or array based methods.
Twist Target EnrichmentNGS Method |
Amplicon SequencingNGS Method |
Array-Based AnalysisNGS Method |
|
| Design Method | Fully customizable panels | Fixed amplicons; redesign requires new primers | Fixed content; no new targets |
| Performance traits | Uniform coverage, even in GC-rich regions | Uneven due to PCR bias | Limited to preset markers |
| Variant classes | Detects SNVs, indels, CNVs, fusions, isoforms | Good for small SNVs; poor for complex variants | Only known variants |
| Throughput / Format | Scales from small to million-probe panels | Hard to scale large panels | Must buy new arrays for expansion |
| View offerings |
Twist Target Enrichment
NGS Method
Design Method
Fully customizable panels
Performance traits
Uniform coverage, even in GC-rich regions
Variant classes
Detects SNVs, indels, CNVs, fusions, isoforms
Throughput / Format
Scales from small to million-probe panels
Amplicon Sequencing
NGS Method
Design Method
Fixed amplicons; redesign requires new primers
Performance traits
Uneven due to PCR bias
Variant classes
Good for small SNVs; poor for complex variants
Throughput / Format
Hard to scale large panels
Array-Based Analysis
Non-sequencing Method
Design Method
Fully customizable panels
Performance traits
Uniform coverage, even in GC-rich regions
Variant classes
Detects SNVs, indels, CNVs, fusions, isoforms
Throughput / Format
Scales from small to million-probe panels
How it works
Target Enrichment Sequencing Workflow
Target enrichment selectively captures the regions that matter; genes, exons, splice sites, or CpG islands; focusing sequencing power for deeper coverage, fewer wasted reads, and faster results.
Why choose us
Complete your Target
Enrichment Workflow
Library Prep that Powers Exceptional Target Enrichment
Twist’s library prep uses engineered enzymes and optimized chemistry to generate consistent libraries with optimal inserts, strong uniformity, and high on target performance.
Hybridization Chemistry Engineered for High Fidelity Capture
Twist’s target enrichment optimizes hybridization to deliver balanced ligation, uniform inserts, reduced off target noise, and stronger sensitivity.
Fixed and Custom Panels Engineered for Precise, Reliable Target Enrichment
Twist’s fixed and custom panels use optimized probe designs and high uniformity capture to deliver consistent coverage, balanced performance, and strong sensitivity.
NEW
Introducing the Twist TrueAmp Library Preparation Kit
Power your sequencing with Twist’s enzyme-driven library prep; engineered to deliver more data from your sample, in any workflow.
What we offer
Featured Solutions
For Research Use Only. Not for Diagnostic Procedures.
