The high costs of development of biologics demand improvements in efficiency at all stages of the drug development pipeline, including antibody discovery and optimization. Utilizing its proprietary DNA writing technology to create oligo pools, genes, and synthetic libraries, Twist Bioscience can support the Biopharma industry at multiple stages of their pipeline. Here, we discuss the use of Twist's synthetic biology tools and high diversity synthetic antibody libraries for discovery, and how deploying these tools can dramatically improve the efficiency of cancer therapeutic discovery and scale up pipelines.