Interested in partnering with us?
Interested in partnering with us?
Interested in partnering with us?
ÜBERSICHT
ÜBERSICHT

Übersicht 

Introducing Twist Alliance Panels, a curated collection of high-quality target enrichment panels designed in partnership with leading scientific institutions. 

In combining Twist’s world-class oligonucleotide synthesis platform with our scientific partners’ deep area expertise, Twist Alliance panels provide ready-made panels to help accelerate your research. Why spend time designing panels when experts have already done the work for you?

Partner With Us

Are you interested in building a panel that is not already part of the Twist Alliance Panel portfolio? 

Partner with us to commercialize

 

Übersicht 

Introducing Twist Alliance Panels, a curated collection of high-quality target enrichment panels designed in partnership with leading scientific institutions. 

In combining Twist’s world-class oligonucleotide synthesis platform with our scientific partners’ deep area expertise, Twist Alliance panels provide ready-made panels to help accelerate your research. Why spend time designing panels when experts have already done the work for you?

Partner With Us

Are you interested in building a panel that is not already part of the Twist Alliance Panel portfolio? 

Partner with us to commercialize

 

Explore Our Panels

The Twist Alliance Panels are designed to give you a head start, bringing together expertise from multiple disciplines for superior target enrichment, for applications ranging from cancer diagnostics to carrier screening. If none of the panels look quite right for your needs, each panel can be customized with spike-in coverage where you need it. Are you interested in partnering with us to commercialize a new panel? Kontakt.

Helping you skip the design, build, test, learn cycle.

Twist Alliance Diversity SNP Panel

A prevalent issue with historical genotyping tools is their bias toward a small number of ethnicities, leaving significant portions of humanity underrepresented in Genotyping-by-Sequencing (GBS) workflows. As an example, microarray platforms only offer fixed content updated occasionally, compounding this challenge.

Researchers can solve these inefficiencies and inequities by utilizing target capture-based NGS workflows with probe panels designed for diversity and flexibility.

As part of Twist’s growing Targeted GBS portfolio, the Twist Diversity SNP Panel gives researchers a new flexible ethnicity-neutral gold standard to use for GBS.

Scientists have the freedom to use the panel as a stand-alone genotyping panel or as a spike-in into the Twist Human Comprehensive Exome panel. Its design is also customizable—additional probes covering regions of interest can be synthesized on Twist's DNA synthesis platform.

Das Twist Diversity SNP Panel wurde in Partnerschaft mit Leitern des Regeneron Genetics Center kuratiert. Dieses Panel wurde so konfiguriert, dass es vollständig in bestehende, komplett automatisierte Exom-Verarbeitungs-Workflows integriert werden kann, und liefert Basenaufrufe und imputierte Varianten.

Genotyp-Imputationen können mit verfügbaren Open-Source-Tools berechnet werden. Please reach out to Customer Support to get a copy of our imputation guide to getting started with imputation analysis tools.
 

Hinweis: Der Inhalt des Diversity SNP Panel wurde noch nicht vollständig durch den gesamten Twist-Arbeitsablauf validiert. Bitte wenden Sie sich an den Kundendienst, um Empfehlungen bei der Assay-Einrichtung zu erhalten.

PROBES

640k

SNPs COVERED

1.4M

SENSITIVITY

Imputation of most variants down to MAF of 0,1% or less

Ordering Information

104374

Twist Diversity SNP Panel, 2 Reaktionen

104375

Twist Diversity SNP Panel, 12 Reaktionen

104376

Twist Diversity SNP Panel, 96 Reaktionen

104393

Twist Diversity SNP Panel, 16 Proben vollständiges Kit mit Standard Hyb

104394

Twist Diversity SNP Panel, 96 samples complete kit with Standard Hy

Twist Alliance Pan-cancer Methylation Panel - 1.5 MB

Methylation sequencing is a sensitive tool for detecting and tracing the origin of cancer cells. But like any sequencing project, there is a tradeoff between breadth and depth of coverage. If you’re ready to focus on cancer-specific methylation patterns, this is the panel for you. Experts at AnchorDx partnered with Twist to create a custom target enrichment panel that focuses specifically on targets relevant to 31 different cancers. 

The Twist Alliance Pan-cancer Methylation Panel - 1.5 MB provides deep coverage of clinically focused targets that allow for the study of methylation patterns that may be relevant to early cancer detection and diagnosis from tumor and liquid biopsy samples. Designed in collaboration with experts at AnchorDx and constructed using Twist’s world-class oligonucleotide synthesis platform, this panel provides a high on-target rate and high uniformity, and has been validated with the Twist Methylation workflow using liquid biopsy samples of breast cancer, colorectal cancer, and non-small cell lung cancer.

 

Panel Design

  • 31 cancer types, 47 disease entities, based on TCGA database
  • 13,090 Probes 
  • 126k CpG sites involved
  • ~12k Differentially Methylated Regions (DMRs)
  • 9k of 12k (74%) overlapped with the CpG islands

Hinweis: The Twist Alliance Pan-cancer Methylation Panel - 1.5 MB is not ISO-13485 certified

Ordering Information

104694

Twist Alliance Pan-cancer Methylation Panel - 1,5 MB, 2 Reactions

104695

Twist Alliance Pan-cancer Methylation Panel - 1,5 MB, 12 Reactions

104696

Twist Alliance Pan-cancer Methylation Panel - 1,5 MB, 96 Reactions
Twist Methylation Workflow

101976

NEBNext® EM-seq™ Kit for Twist Targeted Methylation Sequencing, 96 Samples*

103557

Twist Methylation Enhancer, 12 Reaktionen

100578

Twist Universal Blockers, 12 Reaktionen

100983

Twist Binding and Purification Beads Kit, 12 Reaktionen

101174

Twist Fast Hybridization and Wash Kit, 12 Reaktionen

103496

Twist Targeted Methylation Sequencing Workflow, 96x12 Reactions

*2 reaction and 12 reaction sizes are also available for enrichment

Twist Alliance Clinical Research Exome - 34.9 MB

The Twist Alliance Clinical Research Exome helps support the Broad Institute Genomics Platform and was designed using validated data from clinical patient samples. The panel leverages Twist’s flexible NGS platform to customize content easily and quickly, resulting in a comprehensive survey of the exome with supplemental enrichment of clinically relevant areas of the genome related to cancer as well as rare and inherited diseases. By leveraging the best-in-class uniformity of Twist NGS probes, the assay enables a per sample cost and throughput efficiency that Broad has already leveraged to process more than 250,000 samples to date, keeping it on the leading edge of exome sequencing.

The full design of this panel includes the Twist Core exome, the mitochondrial genome, and additional validated coding and non-exonic regions of interest such as the ACMG73 genes, supplemental coverage of regions from OMIM and COSMIC, and specific Broad-defined targets. 

Hinweis: The Twist Alliance Clinical Research Exome - 34.9 MB content has not been fully validated through the complete Twist workflow. Bitte wenden Sie sich an den Kundendienst, um Empfehlungen bei der Assay-Einrichtung zu erhalten. 

Hinweis: The Twist Alliance Clinical Research Exome - 34.9 MB is not ISO-13485 certified.

 

Ordering Information

104032

Twist Alliance Clinical Research Exome - 34,9 MB, 2 Reactions Kit

104033

Twist Alliance Clinical Research Exome - 34,9 MB, 12 Reactions Kit

104034

Twist Alliance Clinical Research Exome - 34,9 MB, 96 Reactions Kit

Twist Alliance VCGS Exome - 40.1 MB

Where routine testing has failed to provide a diagnosis, physicians often turn to DNA sequencing panels for answers, particularly when a heritable disease is suspected. But without expert guidance, it can be hard to know which panel is the right panel.
Drawing on decades of experience in clinical genomics, Victorian Clinical Genetics Services (VCGS) has partnered with Twist to design a diagnostic panel—Twist Alliance VCGS Exome - 40.1 MB—that covers the whole exome, with dedicated coverage boosting over clinically relevant genes (Mendeliome). In designing this panel, special care was given to ensuring additional coverage of clinically relevant loci that fall outside the gene coding regions traditionally targeted by exomes (i.e. known pathogenic loci in non-coding regions).
The Twist Alliance VCGS Exome - 40.1 MB panel is a best-in-class, highly uniform panel that can help streamline the identification of heritable disease-linked alleles, be it through carrier screening or pre- and post-natal testing.

Hinweis: The Twist Alliance VCGS Exome - 40.1 MB content has not been fully validated through the complete Twist workflow. Bitte wenden Sie sich an den Kundendienst, um Empfehlungen bei der Assay-Einrichtung zu erhalten.

Hinweis: The Twist Alliance VCGS Exome - 40.1 MB is not ISO-13485 certified.

Total probes

425.4K

Includes the Twist Comprehensive Exome of

394.1K probes

and content curated by VCGS of

31.3K probes

Ordering Information

104282

Twist Alliance VCGS Exome - 40,1 MB, 2 Reactions Kit

104283

Twist Alliance VCGS Exome - 40,1 MB, 12 Reactions Kit

104284

Twist Alliance VCGS Exome - 40,1 MB, 96 Reactions Kit