Precision and Diversity

Spread-Out Low Diversity (SOLD) libraries, the latest innovation in libraries from Twist, provide a quick and precise tool for mapping protein sequences to explore the complex relationship between a protein and its environment. With this new library researchers can optimize the development of enzymes with improved specificity, thermostability, processivity and performance.

Download the Product Sheet

Flexibility and Quality

The SOLD library is a powerful tool that enables the exploration of the sequence space encoded by mutating multiple positions simultaneously scattered across the parental sequence to generate a diverse library of proteins.

Explore multiple mutations simultaneously
Attain a precise and cost effective alternative to NNK, TRIM, error-prone PCR, random mutagenesis, and DNA shuffling
Leverage the power of Twist’s patented silicon-based synthesis platform that requires no template
Avoid unwanted motifs, unwanted restriction sites, and undesirable mutations

Explore Spread Out Low Diversity Libraries

Connect With Your Twist Libraries Rep

Genes

Oligo Pools

NGS Target Enrichment Solutions

Variant Libraries

Antibody Discovery

Spread-Out Low Diversity Libraries

Precision and Diversity

Flexibility and Quality