Phage Display Antibody Discovery

Zero in on the Sequences that Matter Most

OVERVIEW
BENEFITS

Explicitly Test All the Sequences You Want

Phage display enables rapid, high-throughput screening of billions of diverse antibody sequences.

Our precision DNA synthesis technology allows us to create high-diversity validated phage display libraries that focus explicitly on the sequences you need to move your program to the clinic. Our novel phage display libraries, whether from our Library of Libraries or a custom Library for your specific needs, maximize diversity to enhance your probability of finding promising hits while excluding undesirable sequences that lead to developability and manufacturability complications.

In Vitro Discovery, Shaped to Your Needs

Phage Display: One Size does Not Fit All Target Types

Phage display offers several benefits for antibody discovery. One significant advantage is its fixed sequence diversity, which can be custom-designed to match specific program requirements. At Twist Biopharma Solutions, phage display approaches are just one of our core competencies. Our biologics experts will collaborate with you to design and deliver high-quality antibodies that fit your criteria using upstream, parallel, and downstream capabilities. Together, that means faster, more cost-effective discovery and optimization of functional lead antibodies.

Off the Shelf or Custom Solutions

We rapidly and explicitly synthesize libraries with pre-defined diversity. We’ve constructed and validated a collection of phage display libraries – our Library of Libraries – featuring naïve human diversity, rationally designed with antibody structural considerations, or diversity computationally tailored to target high-value molecules such as carbohydrates, hyperimmune epitopes, and structural motifs. We can also construct custom libraries focused on a framework or hard-to-drug targets of your choice.