Rapid mAb Discovery against Cell Surface Receptor Based on B cell Screening on Adherent Cell Lines

Abstract: Advanced high-resolution single B cell screening for rapid antibody discovery using the Beacon platform. Just 29 DAYS from immunization to sequence for a cell surface target.

Covered in this Case Study

Goal: delivery of a diverse panel of IgG and scFv anti-Target X binders

The partner had previously attempted in vivo discovery in house and suspected the immunogen to be poorly immunogenic

Successful antibody discovery campaign against a known poorly-immunogenic cell surface target

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Genes

Oligo Pools

NGS Target Enrichment Solutions

Variant Libraries

Antibodies

Rapid mAb Discovery against Cell Surface Receptor Based on B cell Screening on Adherent Cell Lines

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