ACE2 mimetic antibody potently neutralizes all SARS-CoV-2 variants and fully protects in XBB.1.5 challenged monkeys

bioRxiv, Jul 2023

DOI: 10.1101/2023.07.18.549530

ACE2 mimetic antibody potently neutralizes all SARS-CoV-2 variants and fully protects in XBB.1.5 challenged monkeys

Fenwick, Craig ; Turelli, Priscilla ; Duhoo, Yoan ; Lau, Kelvin ; Herate, Cécile ; Marlin, Romain ; Lamrayah, Myriam ; Campos, Jérémy ; Esteves-Leuenberger, Line ; Farina, Alex ; Raclot, Charlène ; Genet, Vanessa ; Fiscalini, Flurin ; Cesborn, Julien ; Perez, Laurent ; Dereuddre-Bosquet, Nathalie ; Contreras, Vanessa ; Lheureux, Kyllian ; Relouzat, Francis ; Abdelnabi, Rana ; Foo, Caroline S. ; Neyts, Johan ; Leyssen, Pieter ; Lévy, Yves ; Pojer, Florence ; Stahlberg, Henning ; Le Grand, Roger ; Trono, Didier ; Pantaleo, Giuseppe

PRODUCTS USED

Genes

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ABSTRACT

The rapid evolution of SARS-CoV-2 to variants with improved transmission efficiency and reduced sensitivity to vaccine-induced humoral immunity has abolished the protective effect of licensed therapeutic human monoclonal antibodies (mAbs). To fill this unmet medical need and protect vulnerable patient populations, we isolated the P4J15 mAb from a previously infected, vaccinated donor, with

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PRODUCTS USED

Genes

Genes

Oligo Pools

NGS Target Enrichment Solutions

Variant Libraries

Synthetic Controls

Antibody Discovery