A high-throughput structural system biology approach to increase structure representation of proteins from Clostridioides difficile

Microbiology resource announcements, Sep 2023 | e0050723

DOI: 10.1128/MRA.00507-23

A high-throughput structural system biology approach to increase structure representation of proteins from Clostridioides difficile

Rosas-Lemus, Monica ; Dey, Supratim ; Minasov, George ; Tan, Kemin ; Anderson, Spencer M ; Brunzelle, Joseph ; Nocadello, Salvatore ; Shabalin, Ivan ; Filippova, Ekaterina ; Halavaty, Andrei ; Kim, Youngchang ; Maltseva, Natalia ; Osipiuk, Jerzy ; Minor, Wladek ; Joachimiak, Andrzej ; Savchenko, Alexei ; Anderson, Wayne F ; Satchell, Karla J F ; Center for Structural Biology of Infectious Diseases team members,

PRODUCTS USED

Genes

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ABSTRACT

Clostridioides difficile causes life-threatening gastrointestinal infections. It is a high-risk pathogen due to a lack of effective treatments, antimicrobial resistance, and a poorly conserved genomic core. Herein, we report 30 X-ray structures from a structure genomics pipeline spanning 13 years, representing 10.2% of the X-ray structures for this important pathogen.

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PRODUCTS USED

Genes

Genes

Oligo Pools

NGS Target Enrichment Solutions

Variant Libraries

Synthetic Controls

Antibody Discovery