A highly active and regioselective cannabigerolic acid synthase engineered from a promiscuous prenyltransferase NphB

Catalysis Science & Technology, Apr 2025 | 15 (11), 3363-3371

DOI: 10.1039/d4cy01367k

A highly active and regioselective cannabigerolic acid synthase engineered from a promiscuous prenyltransferase NphB

Park, Ye Seop ; Kim, Minju ; Na, Chae Yeong ; Ham, Hyeon Woo ; Cho, Jun-Young ; Park, Boyoung ; Jung, Cheulhee ; Park, Daechan ; Yoo, Tae Hyeon

PRODUCTS USED

Genes

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ABSTRACT

We report a highly active and regioselective NphB prenyltransferase variant (V49W/S214H/A232S/Y288P) to synthesize cannabigerolic acid using geranyl pyrophosphate and olivetolic acid efficiently.

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PRODUCTS USED

Genes

Genes

Oligo Pools

NGS Target Enrichment Solutions

Variant Libraries

Synthetic Controls

Antibody Discovery

A highly active and regioselective cannabigerolic acid synthase engineered from a promiscuous prenyltransferase NphB

PRODUCTS USED

ABSTRACT

PRODUCTS USED

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