Monkeypox Virus Clade IIa Infections, Liberia, 2023-2024

Emerging infectious diseases, Aug 2025 | 31 (9), 1848-1851

DOI: 10.3201/eid3109.250271

Monkeypox Virus Clade IIa Infections, Liberia, 2023-2024

Nyan, Dougbeh Chris ; Berry, Irina Maljkovic ; Shobayo, Bode I ; Mehta, Monika ; Worwa, Gabriella ; Hirsch, Shawn ; Klim, Sarah E ; Taweh, Fahn ; Donzo, Kalilu S ; Freeman, B M ; Corvah, Alberta B ; Jaryan, Francis ; Gilayeneh, Julius S M ; Crozier, Ian ; Renken, Courtney ; McNay, Laura ; Moses, J Soka ; Kuhn, Jens H ; Hensley, Lisa E ; Zufan, Sara E

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ABSTRACT

We performed monkeypox virus genome sequencing on clinical samples from Liberia, yielding 5 clade IIa genomes. Our analysis found no evidence of sustained human-to-human transmission, suggesting independent zoonotic spillovers from a diverse viral lineage. Public health officials should continue monitoring and sequencing efforts to identify emerging monkeypox virus lineages.

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