SARS-CoV-2 whole-genome classification analysis, protein homology modelling and elucidation of associated protein functions

ABSTRACT

The most recent whole-genome sequence of SARS-CoV-2 was published on NCBI on 13th March 2020, with accession no. NC_045512. The protein products, genetic features, sequence length, NCBI reference sequence, protein structures (published/ homology modelling) and functions are discussed and analysed in this paper. Multiple sequence alignment is performed and Phylogenic tree is prepared for the 4 closely related coronavirus species. This study provides the whole genome analysis with protein homology structures and elucidates functions of structurally similar proteins for further exploration and contributes to the search for anti-SARS-CoV-2 drugs. The application of this data in new vaccine development techniques such as Rapid-Response Platform and a possibility of a recombinant SARS-CoV-2 are discussed in this paper.