Satellite lesions versus intrahepatic metastasis in multifocal intrahepatic cholangiocarcinoma: Prognostic impact and genomic profiling

Hepatology (Baltimore, Md.), Oct 2025

DOI: 10.1097/HEP.0000000000001594

Satellite lesions versus intrahepatic metastasis in multifocal intrahepatic cholangiocarcinoma: Prognostic impact and genomic profiling

Wei, Tao ; Ma, Zhi-Jie ; Guo, Shouliang ; Weiss, Matthew ; Popescu, Irinel ; Marques, Hugo P ; Aldrighetti, Luca ; Maithel, Shishir K ; Pulitano, Carlo ; Bauer, Todd W ; Shen, Feng ; Poultsides, George A ; Soubrane, Oliver ; Martel, Guillaume ; Groot Koerkamp, Bas ; Endo, Itaru ; Liang, Tingbo ; Lyu, Yi ; Pawlik, Timothy M ; Zhang, Xu-Feng ; Intrahepatic Cholangiocarcinoma Study Group,

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ABSTRACT

Multifocal intrahepatic cholangiocarcinoma (ICC) is typically categorized as satellite lesions (SL) or intrahepatic metastasis (IM). Clinical staging and prognostic significance of multifocal ICC are a topic of debate.ICC patients with solitary or multifocal tumors undergoing curative-intent surgical resection were identified from an international multi-institutional database. SL and IM were classified according to distribution patterns. Among 1,064 patients included in the cohort, 358 had multifocal tumors that were defined as IM (n=95) or SL (n=263). Isolated AJCC Stage II of multifocal ICC disease was associated with shorter overall (OS)(median: 26.1 vs. 60.0 mo, p

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