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Twist Bioscience HQ
681 Gateway Blvd
South San Francisco, CA 94080
Discovering PARP inhibitor resistance mechanisms using genome-wide and focused CRISPR screens
Dr. Stephen Pettitt explores the limits of genome-wide targeted mutagenesis screens and the genetic basis of gene resistance
Presented by
Stephen Pettitt, PhD
Staff Scientist, Institute of Cancer Research, UK
Covered in this Webinar
Learn about the role of Poly-ADP Ribose Polymerase (PARP) in DNA Repair.
How structure-function relationships of PARP1 mutants inform treatment of cancer patients with these drugs.
How to use genome-wide CRISPR screening for mutant discovery.
How to create a highly diverse, sgRNA library from Twist Bioscience for targeted, subtle mutations.
Explore the limits of genome-wide targeted mutagenesis screens and the genetic basis of gene resistance with Dr. Stephen Pettitt, Staff Scientist, Institute of Cancer Research, UK.
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