Introducing Gene Pools
Build something brilliant with unprecedented access to unlimited DNA.
Gene Pools are a revolution in pooled DNA synthesis. Our proprietary pooled assembly platform assembles pools of oligos into pools of genes ranging from 300bp to 1.8 kb. Our Gene Pools platform completely solves the challenges common in pooled assembly workflows, offering an up to 1:3000 error rate*, a 0% chimera rate**, 90% sequence representation within 10x the mean***, and <1% dropout rates**. Cut through the noise caused by unwanted or overrepresented sequences and leave no sequence unscreened
Read this article from Emily Leproust and hear how Gene Pools were developed. Learn how our first-to-market 0% chimera rate pooled assembly technology marks a paradigm shift in high throughput screening.
* Error rate for the previous year was an average of 1/2911 with a standard deviation of 422.
** Dropout rate refers specifically to accepted sequences. Of fragments accepted in fiscal year 2025, >99% were shipped.
*** Uniformity metrics are only applicable for sequences within a maximum 15% length variation.
**** Gene pools up 50k fragments are shipped within 10BD, up to 150k fragments are shipped within 15BD. This timeframe refers to the typical processing and handling time within our facilities before your order is handed over to the shipping carrier. Actual delivery times will vary depending on your location, the chosen shipping method, and the carrier's handling procedures.
Introducing Gene Pools
Build something brilliant with unprecedented access to unlimited DNA.
Gene Pools are a revolution in pooled DNA synthesis. Our proprietary pooled assembly platform assembles pools of oligos into pools of genes ranging from 300bp to 1.8 kb. Our Gene Pools platform completely solves the challenges common in pooled assembly workflows, offering an up to 1:3000 error rate*, a 0% chimera rate**, 90% sequence representation within 10x the mean***, and <1% dropout rates**. Cut through the noise caused by unwanted or overrepresented sequences and leave no sequence unscreened
Read this article from Emily Leproust and hear how Gene Pools were developed. Learn how our first-to-market 0% chimera rate pooled assembly technology marks a paradigm shift in high throughput screening.
* Error rate for the previous year was an average of 1/2911 with a standard deviation of 422.
** Dropout rate refers specifically to accepted sequences. Of fragments accepted in fiscal year 2025, >99% were shipped.
*** Uniformity metrics are only applicable for sequences within a maximum 15% length variation.
**** Gene pools up 50k fragments are shipped within 10BD, up to 150k fragments are shipped within 15BD. This timeframe refers to the typical processing and handling time within our facilities before your order is handed over to the shipping carrier. Actual delivery times will vary depending on your location, the chosen shipping method, and the carrier's handling procedures.
To rigorously benchmark this platform, we assembled multiple gene pools, each consisting of thousands of sequences at lengths between 650bp and 1.8kb. These pools were designed with mean pairwise similarities up to 97%, classifying them as “chimera-prone” if they were built through standard pooled assembly methods. We then employed high-fidelity PacBio single-molecule sequencing to precisely quantify the percentage of perfect molecules (no synthesis errors, template switching, or chimeras).
Figure 1.Gene pool errors map to a poisson distribution, and show 0% chimera rates.
Figure 2. Gene pools show high uniformity at all sequence lengths tested, and less than 1% dropout rates.
Figure 3. Gene pools show >90% full length sequences
To rigorously benchmark this platform, we assembled multiple gene pools, each consisting of thousands of sequences at lengths between 650bp and 1.8kb. These pools were designed with mean pairwise similarities up to 97%, classifying them as “chimera-prone” if they were built through standard pooled assembly methods. We then employed high-fidelity PacBio single-molecule sequencing to precisely quantify the percentage of perfect molecules (no synthesis errors, template switching, or chimeras).
Figure 1.Gene pool errors map to a poisson distribution, and show 0% chimera rates.
Figure 2. Gene pools show high uniformity at all sequence lengths tested, and less than 1% dropout rates.
Figure 3. Gene pools show >90% full length sequences
Start your order
Get unprecedented access to unlimited DNA with Gene Pools
- Step 1: Complete the contact details form on this page
- Step 2: Download the Gene Pools submission Form for your Pool design
- Step 3: Upload the completed submission form to the "Submit File" tab on this page
Ready to Submit?
- Step 1: Upload completed submission form
- Step 2: Our Gene Pools Team Experts will review your project
- Step 3: Gene Pools Team verifies the project and will reach out to you with a quote
- Step 4: Once the quote is accepted by the customer, Gene Pools Team will send the project to the production team
If you have any questions, please feel free to email us at [email protected]
Start your order
Get unprecedented access to unlimited DNA with Gene Pools
- Step 1: Complete the contact details form on this page
- Step 2: Download the Gene Pools submission Form for your Pool design
- Step 3: Upload the completed submission form to the "Submit File" tab on this page
Ready to Submit?
- Step 1: Upload completed submission form
- Step 2: Our Gene Pools Team Experts will review your project
- Step 3: Gene Pools Team verifies the project and will reach out to you with a quote
- Step 4: Once the quote is accepted by the customer, Gene Pools Team will send the project to the production team
If you have any questions, please feel free to email us at [email protected]
