Resurrecting Plant Immunity With Large-Scale Protein Engineering

Bacteria, oomycetes, and other pathogens extract a heavy toll on the farming community. Together, they’re responsible for a near 20% reduction in global crop production each year. Farmers have long sought to identify and breed resistant crop strains, but doing so can be an arduous task that spans more than a decade. Resurrect Bio is seeking to change this, enabling farmers to hone resistant pathogen resistance in just a single year. Using a combination of AI, DNA synthesis, and a rapid in planta screening platform, Resurrect Bio identifies and screens tens of thousands of protein-protein interactions to identify how pathogens suppress plant immune systems. Through precise genome engineering, the team can then resurrect plant immunity, giving farmers a unique leg up in the eternal fight against pests.


Covered in this Case Study
How plant pathogens suppress immunity
How AI is helping Resurrect Bio both identify and disrupt these key pathogen-host interactions
How Twist’s ability to synthesize custom, AI-designed gene fragments enables the Resurrect team to overcome a common AI bottleneck, ultimately to resurrect plant immunity.
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