MRD Express: Rapid, Scalable, and High-Performance Custom Target Enrichment for Minimal Residual Disease Monitoring

See the probe engineering behind ultra-sensitive, rapid turnaround target enrichment for MRD research.

Personalized MRD research panels have always forced a choice: wait weeks for a highly sensitive custom design or move fast with a panel that loses performance in difficult regions.

This poster, presented at AACR 2026, walks through the experiments behind a novel LNA probe boosting strategy and optimized tiling design that close that gap, including real sensitivity data down to 10 ppm and coverage rescue at some of the toughest low GC targets in the genome. Fill out the form to get full access.

Covered in this poster

How LNA (locked nucleic acid) boosted probes rescue coverage at low GC targets, including recurrently altered loci like ROS1 and PTEN

Why double stranded staggered probe tiling significantly increases usable sequencing depth over standard single probe designs

Sensitivity data distinguishing a 10-ppm variant signal from blank across a simulated MRD dilution series

The full workflow timeline showing turnaround of ~24 hours from panel order to shipment

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MRD Express: Rapid, Scalable, and High-Performance Custom Target Enrichment for Minimal Residual Disease Monitoring

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