Libraries
Oligo Pools
Twist Bioscience Silicon Chip
Twist Bioscience HQ
681 Gateway Blvd
South San Francisco, CA 94080
For AI drug discovery
The Biological Tech Stack
Get trusted data in as few as 5 days.
Build great models. De-risk candidates.
Build great models. De-risk candidates.
The Biological Tech Stack
Essentials to accelerate your IND journey
Build your discovery program on a solid biological foundation. With Twist, plug into the Biological Tech
Stack at any layer.
A team of scientists guides you to efficiently move your program forward.
Off-the-shelf model-training datasets available for immediate licensing. Get IND-ready with rapid
sequence to data solutions.
Get full-length IgGs in as few as 5 days. Any format your program needs, monospecific to
multispecific.
Generate the foundational material for medium-to-high throughput sequence-function annotation or model
validation.
All AI drug discovery programs require DNA. Ensure your program uses the gold standard: Twist Genes.
High throughput protein production and annotation workflows are made possible on a foundation of
scalable DNA synthesis.
How Twist can help
Never compromise on:
Speed
Get off-the-shelf data today. Characterize IgGs in as fast as 5 days. Order directly via our API.
Scale
Run more candidates and more targets in parallel with our highly scalable silicon platform.
AI-readiness
All datasets are delivered machine-readable, ready for your pipeline.
Security
Twist protects your IP through US manufacturing and ISO-certified data handling.
Guidance
We provide expertise and flexible customization to any program.
Growth
From DNA to data, Twist provides solutions for every stage of the biological continuum.
Results are specific to the institution where they were obtained and may not reflect the results achievable
at other institutions.
Annotated Data
Data your way, fast
Data starting at 5 days. Get packages fit to your program's stage.
Fast iteration
Coming soon
Express discovery
Iterate on your designs in days
Expression
Cell-free
Assays SPR
Sequences
100's to 1000's
Input
Your therapeutic target(s) + unvalidated hits
Output
Ranked affinity data, ready to feed back into your next design round
Format
VHH, scFv
Full signal
Express discovery plus
Rank binders, downselect on developability
Expression
Mammalian
Assays SPR/ BLI, BVP ELISA,
AC-SINS, aSEC, hydrophobic
Sequences
100's to 1000's
Input
Your therapeutic target(s) + unvalidated hits
Output
Ranked affinity data, downselection to desired developability assays
Format
Full-length IgG (hIgG1, hIgG4, mIgG2a, rabbit), Fab, scFv, VHH formats, B-Body, and
bispecifics (KiH, monovalent)
Massive scale
Pooled discovery
Build model training datasets
Expression
Yeast
Assays Yeast display, NGS,
optional SPR
Sequences
100,000's
Input
Your therapeutic target(s) and unvalidated hit sequences
Output
Screened candidates identified in yeast display and ranked affinity data plus optional
binding data
Format
scFv, VHH, Fab, IgG
Breadth at scale
Biologics profiling panel
Profile developability across many hits at once
Expression
Mammalian
Assays Full developability
(HI, OVA, BVP ELISA, AC-SINS, nanoDSF, and aSEC) with/ without binding (BLI or SPR)
Sequences
10's to 100's
Input
Your unvalidated hits
Output
A comparable profile across every candidate in your set
Format
Full-length IgG (hIgG1, hIgG4, mIgG2a, rabbit), Fab, scFv, VHH formats, B-Body, and
bispecifics (KiH, monovalent)
Confident selection
Stability assessment
Narrow your shortlist with stability data
Expression
Mammalian
Assays Thermostability with
or without DLS
Sequences
10's to 100's
Input
Your unvalidated hits
Output
A stability ranking across your shortlist, so you commit to a clinical candidate with
confidence
Format
Full-length IgG (hIgG1, hIgG4, mIgG2a, rabbit), Fab, scFv, VHH formats, B-Body, and
bispecifics (KiH, monovalent)
Off-the-shelf
Available now
Model-training datasets
Train your model from day one
Expression
Mammalian
Assays Phage library
Sequences
100,000's
Input
ROR1, BCMA, TROP2, CLEC9A, TSLP
Output
Structured training data, available now, no new production required
Format
scFv, VHH, Fab, IgG
Need help choosing?
Talk to an expert
Assay suite
Built for IND. Run at AI speed.
Run the assays you need to reach IND, delivered as structured, AI-ready data.
Determine top candidates by confirming, ranking, and binning your binders. Example dataset shown for each
assay.
Confirm Binding by Flow Cytometry
Confirm target engagement on cells expressing native antigen. Generates dose-response binding curves
for ranking.
Single-Point Kinetics by BLI
Rapidly confirm binding across large antibody panels at one concentration for early hit triage,
before committing to full kinetic analysis.
KD Affinity Determination by BLI
Determine full kinetics and affinity across a concentration series. Provides orthogonal confirmation
to SPR.
KD Affinity Determination by SPR
Determine full binding kinetics (ka, kd, KD) for large antibody panels using high-throughput surface
plasmon resonance.
Epitope Binning by SPR
Map competitive binding relationships across large antibody panels to identify epitope families and
guide lead selection.
Epitope Binning by BLI
Map competitive binding to identify epitope diversity and guide lead selection. Ideal for smaller
panels.
Flag aggregation, stability, and polyspecificity risk early, benchmarked to clinical reference antibodies.
Selected assays and datasets are shown below.
Analytical SEC (aSEC)
Quantify monomeric purity and detect aggregates or degradation products.
Thermostability (nanoDSF)
Measure structural integrity under thermal stress, with three parameters per sample.
Polyspecificity Screen (Baculovirus Particle (BVP) ELISA)
Screen for non-specific binding, which correlates with faster serum clearance in vivo.
Self-Interaction Test (Affinity Capture-Self Interaction Nanoparticle Spectroscopy (AC-SINS))
Detect self-interaction propensity, an early predictor of aggregation and clearance risk.
Hydrophobic Interaction Screen (Hydrophobic Interaction, HI)
Rank candidates by surface hydrophobicity, a key driver of aggregation and non-specific binding.
Non-specific Binding Check (Ovalbumin Off-Target)
Screen for off-target binding to ovalbumin, a confirmatory measure of polyspecificity.
Size Distribution (DLS)
Assess particle size homogeneity and flag candidates with high polydispersity as early aggregation
liabilities.
Test function on cells, with custom assays for bespoke needs. Example dataset shown for each assay.
Signaling Assays (Off-the-Shelf)
Quantify agonist or antagonist activity through defined signaling pathways.
Internalization
Quantify receptor internalization extent following antibody engagement.
Custom Assay Development
For programs requiring non-standard cell types, proprietary cell lines, or bespoke readouts not
covered by off-the-shelf panels.
Twist in action
AI drug discovery with Twist
From Sequences to Systems: Designing a Next-Gen Wet Lab
3 weeks
Experimental cycle time
2x
More high-affinity binders identified vs. traditional methods
Discover how pairing Twist's high-throughput antibody production and characterization with Cradle's
generative AI platform creates a seamless make-test cycle; cutting experimental timelines to three
weeks and surfacing more high-affinity leads faster.
High Throughput Antibodies
Affinity Ranking, Epitope Binning, Thermal Stability
Protecting the data well: DNA tools for generating a “Lab-in-the-loop” system for antibody design.
1200
Unique antibody sequences synthesized
3x – 100x
Improvement in binding affinity
See how Twist Gene Fragments helped one leading pharmaceutical company implement a closed
Lab-in-the-Loop system and achieve significant improvements in antibody therapeutic candidates.
Gene Synthesis
Get to Characterization Data in a Matter of Weeks Without Making a Single Protein
10+
Characterization assays available
<15 days
Turnaround time
Discover how Twist's end-to-end antibody production and characterization platform delivers
high-quality, structured datasets across binding, developability, and advanced characterization,
without a wet lab.
High Throughput Antibodies
Binding Assessment, Developability, Advanced Characterization
1/3
Let’s talk about your program
Tell us where you are in your AI drug discovery. Our scientific team will reach out within one business
day to discuss how Twist can meet your program’s needs.
For Research Use Only.
Not for Diagnostic Procedures.
Twist manufactures all materials, runs all characterization assays, and stores all data in facilities within
the United States. ISO 27001 certified for information security.
Turnaround time is defined as the period from receipt of sequence and payment approval, whichever is later, to
delivery, in business days. Cell-free expression is 5 business days; 8 to 10 business days with SPR. Actual
TAT varies with format, order size and sequence complexity.
