A New Way of Designing Your Libraries
The New Library Design Tool is your all in one solution to streamline, optimize, and expedite the DNA Library design and ordering process.
- OVERVIEW
- DATA
- ORDERING
- RESOURCES
The Latest Tool for Mapping Protein Sequences
Spread-Out Low Diversity (SOLD) libraries provide a quick and precise tool for mapping protein sequences to explore the complex relationship between a protein and its environment.
SOLD Libraries are a time- and money-saving tool for researchers who want to efficiently investigate combinatorial possibilities.
A library of precise combinatorial variants with uniform amino acid distribution, balanced codon usage and the ability to avoid unwanted restriction sites, provides the ultimate tool to explore the variant space. All SOLD Libraries are NGS-verified, cloning-ready, and created using Twist’s patented silicon-based synthesis platform, ensuring low error rates.
KEY BENEFITS
Flexibility
- Greater flexibility than the traditional approach
- Suitable for sites with scattered diversity
- No template required
Precision
- No premature stop codons or unwanted codons
- Precise amino acid and codon control
- More precise than traditional methods, e.g. NNK, TRIM and epPCR.
Superior Quality
- SOLD libraries include NGS verification of modified regions
- Rigorous quality control and verification of all variants
- Uniform distribution of amino acids at each variant position
Explore Spread Out Low Diversity Libraries
Learn how the SOLD Libraries enable the exploration of the sequence space encoded by mutating multiple positions simultaneously scattered across the parental sequence to generate a diverse library of proteins.
Introducing the new Library Design Tool
Streamlined Library Design at Your Fingertips
A High-Fidelity Synthetic Construct
Twist’s SOLD Libraries have shown their ability to consistently deliver amino acid distributions that closely match the requested amino acid frequencies, with a uniform distribution of variants and no dropouts
SOLD Library: Diversity is scattered along the WT sequence
Twist's SOLD Libraries have the benefit of precisely incorporating diversity across a wild-type sequence without restricting that diversity to small variant domains. This ability to simultaneously investigate multiple amino acid positions across a sequence allows researchers to investigate, and optimize, the activity of a protein both rapidly and effectively
Design Companion
- Intuitive, interactive portal to easily upload your library sequence file
- Identify potential errors in sequence with instant feedback enabling library validation on the fly
- Save drafts for future reference
Real-time Optimization
- Errors are flagged for review, letting you quickly resolve issues without delays
- Our library design experts are still ready to assist you with any questions
- With our intuitive tool and expert support we can help you find the fastest path to a validated, high-quality library
Faster Process
- Real-time, interactive library design interface supports optimizing your library design and cost efficiently
- Save drafts for future reference
- Automatically generates a Statement of Work (SOW) for your order, expediting the entire ordering process
Expert Support Still at Your Fingertips
If you have any questions, please feel free to email us at library@twistbioscience.com
Take a peek at our Library Design Tool
A New Way of Designing Your Libraries at Twist
Watch Step by Step how to optimize your sequences
START DESIGN NOW
Let’s get Started
The New Digital Library Design (DLD) Tool is your all in one solution to streamline, optimize, and expedite the DNA Library design and ordering process.
Step 1
Log into your account. If you don’t have one, it only takes a few minutes to set it up!
Step 2
Start to design your library in the new interactive libraries design tool which has a step by step “how to” wizard. With this option you can optimize your library in real time with validations on the fly and real-time pricing and receive an SOW at the end of the submission process.
Step 3
Once the quote is accepted by the customer, the Libraries Team will send the project to the production team
Note:
The Libraries Design Tool is not currently available in the APAC region. Please check with your local support team on availability date.
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