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Application Note
Twist Bioscience HQ
681 Gateway Blvd
South San Francisco, CA 94080
Cell-free antibody material for early discovery decisions
For teams validating AI models and prioritizing antibody hits, Twist Express Screening Antibodies combine gene synthesis, cell-free expression, and SPR binding characterization to generate screening-grade full-length IgG, VHH-Fc, and scFv-Fc.
Covered in this technical note
Overview of the Express Screening workflow, from gene synthesis and cell-free expression to Protein A purification and SPR binding characterization
Yield, CE-SDS, and binding data for full-length IgG1, VHH-Fc, and scFv-Fc
Affinity agreement with HEK293-expressed antibodies, run-to-run reproducibility, and a hit-prioritization use case
