Unrivaled speed
Submit a design and your panel ships within a day, accelerating your MRD research workflow.
Twist Bioscience HQ
681 Gateway Blvd
South San Francisco, CA 94080
MRD Express: Sensitive.
Tumor-specific. Fast.
Get hybrid capture panels produced at scale, shipped within a day
after you submit a design.* Never trade sensitivity for turnaround again.
Tumor-informed MRD sequencing panels, built within a day*
MRD Express lets you design a hybrid capture panel around variants in tumor sequencing data, shipping within a day of design submission. Track ctDNA at the depth molecular residual disease research requires, scaled to your workflow volume, with the speed key decisions demand.
Panel synthesis to panel shipped
within 1 day*
Detection above background
10 ppm & below
Probes per panel
up to 10,000
Online panel design
Upload a BED or FASTA file to design and order in minutes. Have full control over your design.
Ultra-sensitive
Capture thousands of tumor-specific variants to detect the faint ctDNA signals typical with MRD research.
Order via your LIMS
For workflows running at scale, Twist APIs turn sequencing data into a placed order with no manual steps.
Is your workflow enterprise-scale?
Automate production of thousands of tumor-informed panels per day, with touchless ordering and manufactured to ISO 13485 standards.
Making tradeoffs? Make them go away
Traditional barriers with other approaches
5+ days with legacy hybrid capture workflows
Narrow with amplicon-based panels (16-64 targets)
Not possible with off-the-shelf or fixed panels
Process bottlenecks increase as order volume increases
MRD Express
Within a day from order to hybrid capture panel shipment
Up to 10,000 tumor-informed probes per panel
MRD panels are configured to exact target set
API integrates directly with LIMS for high volume workflow
Tumor-informed MRD research just got easier
Don't outsource your MRD research. Incorporating MRD Express complements your in-house infrastructure, giving you exceptional control over your workflow, timelines, and costs.
Explore how researchers are tackling residual disease and where Twist could support your workflow.
Join the research conversation
What’s still holding MRD back?
A roundtable with BloodPAC, Stanford, and Twist on what still limits tumor-informed MRD: standardized limit-of-detection definitions, comparing assays across studies, and getting tumor-informed panels back in days, not weeks.
Products used
10,000
Probes per panel
Within a day
Design submission to shipment
Find out how MRD Express is built and what it delivers: same-day panel synthesis, LNA probes that hold coverage where standard designs drop out, and uniform performance from 50 to 5,000 variant sites.
Products used
10 ppm
Detection distinguishable from background
15 ng
cfDNA input
Explore the performance data behind MRD Express: how input mass, sequencing depth, and UMI collapse stringency set mean target coverage, and where detection still separates from background.
Products used
0.003%
Limit of detection achieved
500
Targets per tumor-informed panel
See how IntegraGen built a tumor-informed MRD workflow on Twist panels, pairing whole-exome sequencing of tumor tissue with target enrichment of plasma, then validated it retrospectively at a 0.003% limit of detection.
Products used
See the data behind MRD Express
Reproducibility
One ISO-grade quality standard across every panel, verified lot by lot.
Scalable uniformity
Scale the design without sacrificing coverage.
Probe design
Hard-to-capture low-GC variants stay measurable instead of dropping out.
Sensitivity
Built for calling variants at the fractions MRD research actually encounters.
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Panel Specs
| Specification | Detail |
|---|---|
|
Panel size |
1 – 10,000 probes |
|
Reaction pack size |
6 reactions |
|
Probe design |
120bp, LNA incorporated probes, double-stranded printing |
|
Turnaround time |
Ships within one day* upon design submission (same-day synthesis, ahead of the daily cutoff) |
|
Ordering |
eCommerce (self-guided BED/FASTA upload) or API (touchless, LIMS-integrated) |
|
Bulk ordering |
Up to 96 panels on a single quote |
|
Tube formats |
0.5 mL Sarstedt, FluidX or Matrix (available through API) |
|
Storage |
-20°C (label states -25°C to -15°C) |
Order online in five simple steps
Upload target file
Configure panel design
Review panel design
Review panel coverage
Place your order
Ready to get started?
Start your design now or speak with an expert to scope your project.
Control each detail of panel design
Drag and drop BED, FASTA, CSV, TSV or TXT files. Each file becomes its own panel design.
Choose your reference genome and tiling density, protect key regions, or edit many panels at once.
Follow live design status, see probe counts and prices, and download BED files that flag coverage gaps.
Resubmit with your uncovered-bases file as protected regions to cover them, at a higher off-target rate.
Match your reference genome, then load the covered and uncovered BED files side by side to judge any gaps.
Check probe counts, reactions and price per panel, add shipping details, then submit or save for later.
1/6
Twist solutions for your MRD research
Need help building your workflow?
Connect with our technical team and let’s see how we can
advance your MRD research.
Highlighted resources
120bp probes.
6 reactions per panel.
Up to 96 panels on a single quote.
BED files with target coordinates for us to design against, or FASTA, TSV, TXTor CSV files with the probe sequences you wish to order.
Explore workflows with an expert
We are ready for personalized walkthroughs. Reserve your spot now to see how MRD integrates with your workflow.
Schedule your walkthrough
*Turnaround times are estimates only and are not guaranteed. Actual turnaround may vary based on order specifications, sample characteristics, processing requirements, operational capacity, and other applicable factors. Product information, specifications, features, availability, and timing are subject to change without notice. Twist products are for research use only. They are not intended for the diagnosis, prevention, monitoring, or treatment of a disease or condition. Twist Bioscience assumes no liability regarding the use of its products in unintended applications.
MRD Express orders ship on dry ice as soon as they’re ready. For international orders, our standard ship days are chosen to avoid weekend delays in customs or at closed receiving sites:
- Americas and EMEA: Monday, Thursday, Friday and Saturday
- Asia-Pacific: Friday
Orders ready on Tuesday or Wednesday ship the same day if the carrier expects delivery before the weekend. To avoid any chance of weekend arrival, ask us to hold your order until the next scheduled ship day.
