EN
Support
My Orders
Sign In
Logo Logo Logo

Genetic & Rare Diseases

Find the variants that explain the phenotype

Whole-exome and targeted panel sequencing let you move from patient DNA to candidate variant list with the coverage uniformity and sensitivity that complex disease genetics demands. Twist panels are built to capture what other panels miss

Explore exome panels Talk to a scientist

×
Thank you for requesting a quote
One of our sales experts will get back to you shortly

Supporting Cancer Research Labs

500+

Oncology Publications

10K+

Clinical Trials Enabled

50+

Genetic disease research stalls when capture is uneven. Getting consistent, deep coverage across clinically relevant exonic regions is what separates a confident variant call from an ambiguous one.

Next generation sequencing (NGS) has made exome and targeted panel sequencing the standard entry point for discovering the genetic basis of inherited conditions. But raw read depth alone does not distinguish disease-causing variants from sequencing noise.

The Twist Comprehensive Exome 2.0 Panel was designed around the practical demands of genetic disease research: high on-target rates, uniform coverage across GC-rich and repetitive regions, and broad gene content spanning coding sequences, untranslated regions (UTRs), and clinically curated non-coding elements. 

For labs running cohort-scale discovery or requiring deep coverage of established disease gene sets, the Twist Human Core Exome Plus Panel gives you a refined target space without sacrificing the sensitivity needed to detect rare heterozygous variants. [CITATION-NEEDED: verify Core Exome Plus coverage statistics]

When your study requires a gene list tailored to a specific phenotype, pathway, or patient population, Twist Custom Panels let you define the target space precisely, whether that means 50 genes or 5,000.

Lorem ipsum dolor sit amet consectetur. Pulvinar arcu.

Lorem ipsum dolor sit amet consectetur. Pulvinar arcu.

Lorem ipsum dolor sit amet consectetur. Pulvinar arcu.

Section name

Create high-converting copy that drives results

1 year

Plant trait engineering timeline

10,000s

Of plant effectors screened

Discover how massive-scale synthesis is being paired with AI-driven trait engineering to circumvent the evolutionary “arms race”, and generate crops protected from disease.

Read case study

×

Create high-converting copy that drives results

Antibody Production Services

Related applications

Application name

Product description - Lorem ipsum dolor sit amet consectetur. Aliquam vel odio urna id nulla auctor odio et. Etiam quisque nisl felis egestas neque. Pellentesque nulla massa vulputate habitasse nisl nunc vivamus ultricies. Odio nullam.

Application name

Product description - Lorem ipsum dolor sit amet consectetur. Aliquam vel odio urna id nulla auctor odio et. Etiam quisque nisl felis egestas neque. Pellentesque nulla massa vulputate habitasse nisl nunc vivamus ultricies. Odio nullam.

Application name

Product description - Lorem ipsum dolor sit amet consectetur. Aliquam vel odio urna id nulla auctor odio et. Etiam quisque nisl felis egestas neque. Pellentesque nulla massa vulputate habitasse nisl nunc vivamus ultricies. Odio nullam.

Ready to design your genetic disease sequencing study? Talk to a Twist scientist.

Our scientific team can help you match panel selection to your cohort design, coverage requirements, and downstream analysis pipeline. Whether you need an established exome panel or a custom capture set built around your gene list, we can help you get from sample to variant call efficiently.

Talk to a scientist Explore resources

×
Thank you for requesting a quote
One of our sales experts will get back to you shortly

Twist Bioscience HQ
681 Gateway Blvd
South San Francisco, CA 94080