In vivo antibody discovery in weeks instead of months? We do that.
The Berkeley Lights Beacon-based B cell screening enables high-resolution screening for ideal, rare mAbs in previously impossible timelines.
ADVANCED B CELL SCREENING
Unparalleled speed, screening resolution, and throughput of the Beacon® Platform paired with Abveris's mAb discovery expertise
These videos break down Abveris’s ability to deliver ideal antibodies against difficult targets including our optimization and application of:
- Generating immune response against difficult targets
- Enrich for antibody-secreting B-cells
- Isolate and interrogate tens of thousands of B cells
- Deep screen in 1 day, including cross-reactivity against multiple cells and many proteins
- Bringing functional screening forward in the mAb screening cascade
- Sequencing and sequence analysis
BEACON-BASED B CELL WORKFLOW
DISCOVERY TIMELINE (IN DAYS)
On Beacon Screening
Single Cell Sequencing
Antibody Expression & Validation
HIGH RESOLUTION B-CELL SCREENING ON THE BEACON® PLATFORM
Advance only antibodies with ideal characteristics by deep screening on Day 1
RUN IN SEQUENTIAL ASSAYS, INCLUDING WITH ADHERENT CELLS
SCREEN FOR IDEAL REACTIVITY IN MULTIPLEXED ASSAYS
FUNCTIONAL ASSAYS INCLUDING REPORTER CELL ASSAYS
This video highlights the immunization expertise that has been developed to generate specific antibodies to challenging targets. Our suite of immunization methods allows our team maximum flexibility when working with a variety of targets.
BERKELEY LIGHTS BEACON ASSAY FORMATS
One of the many advantages of the Beacon is the flexible screening formats available. These formats allow our scientists to identity functional relevant antibodies early in the discovery process, saving time and resources in the subsequent steps of drug development. This video will provide information on how we are able to perform this level of screening in just one day.
SEQUENCE ANALYSIS WORKFLOWS
The sequence analysis performed by our team provides exceptional value to our partners. Our partnership with Geneious Biologics enables us to provide detailed sequence analysis, highlighting developability concerns and other potential issues. This video will go over a typical workflow, including the application of our sequence analysis and examples of information that can be expected in our data reports. Enjoy!
BEACON B CELL SCREENING CASE STUDIES
In this video, Abveris CSO, Colby Souders, PhD, walks through a B cell screening case study using the Berkely Lights Beacon. Check out the video to see how we apply the Beacon for ultra-rapid, high-resolution antibody discovery services!