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Twist Bioscience HQ
681 Gateway Blvd
South San Francisco, CA 94080
Targeted SNP sequencing panel for population diversity studies and large-scale genomic analysis
Enable scalable SNP diversity analysis with a targeted sequencing panel optimized for population genomics and variant discovery. Broad genomic representation and balanced probe design support accurate genotyping, diversity analysis, and comparative genomic studies across large sample cohorts while maximizing sequencing efficiency.
Broad genomic diversity coverage
Comprehensive SNP content supports population genomics and comparative genetic studies.
Scalable variant analysis
Optimized for high-throughput sequencing across large sample cohorts and research studies.
Reliable genotyping performance
Balanced enrichment chemistry improves coverage uniformity and sequencing consistency.
Product data
The Diversity SNP Panel demonstrated excellent capture uniformity (1.35 fold 80 base penalty vs. 1.32 in our exome) and low duplication rates (2.5% vs. 2.9%), matching the extremely high-quality standards expected of Twist Custom Panel designs. Additionally, target-specific metrics such as AT and GC dropout are comparable with exome values, and only 0.005% of SNP positions had zero coverage.
Capture performance for targeted SNP genotyping after 150x raw sequencing coverage. Graphs show the distribution of coverage across target bases comparing SNP and core exome panels. Coverage distribution: the percentage of bases at a given level of coverage. Cumulative coverage: the percentage of bases at or above a given level of coverage. The table presents additional capture metrics obtained using Picard.
We evaluated GBS metrics compared to array-based call rates for the same SNPs using GiAB calls in each of the three samples studied as the gold-standard. Results based on 150X sequencing for GBS are shown across variant types, technologies, and samples from different populations. Precision and sensitivity for the SNP panel matched or exceeded those in arrays, all of which were greater than 99%. Additionally, the genotyping panel allowed us to identify insertions and deletions at rates of over 90% precision and over 88% sensitivity.
Comparison of performance between the Twist SNP panel and a leading genotyping array across GiAB samples from three different populations.
Video
Excellent capture uniformity and low duplication rates
The Diversity SNP Panel demonstrated excellent capture uniformity (1.35 fold 80 base penalty vs. 1.32 in our exome) and low duplication rates (2.5% vs. 2.9%), matching the extremely high-quality standards expected of Twist Custom Panel designs. Additionally, target-specific metrics such as AT and GC dropout are comparable with exome values, and only 0.005% of SNP positions had zero coverage.
Capture performance for targeted SNP genotyping after 150x raw sequencing coverage. Graphs show the distribution of coverage across target bases comparing SNP and core exome panels. Coverage distribution: the percentage of bases at a given level of coverage. Cumulative coverage: the percentage of bases at or above a given level of coverage. The table presents additional capture metrics obtained using Picard.
Highly sensitive and accurate genotyping
We evaluated GBS metrics compared to array-based call rates for the same SNPs using GiAB calls in each of the three samples studied as the gold-standard. Results based on 150X sequencing for GBS are shown across variant types, technologies, and samples from different populations. Precision and sensitivity for the SNP panel matched or exceeded those in arrays, all of which were greater than 99%. Additionally, the genotyping panel allowed us to identify insertions and deletions at rates of over 90% precision and over 88% sensitivity.
Comparison of performance between the Twist SNP panel and a leading genotyping array across GiAB samples from three different populations.
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Excellent capture uniformity and low duplication rates
The Diversity SNP Panel demonstrated excellent capture uniformity (1.35 fold 80 base penalty vs. 1.32 in our exome) and low duplication rates (2.5% vs. 2.9%), matching the extremely high-quality standards expected of Twist Custom Panel designs. Additionally, target-specific metrics such as AT and GC dropout are comparable with exome values, and only 0.005% of SNP positions had zero coverage.
Highly sensitive and accurate genotyping
We evaluated GBS metrics compared to array-based call rates for the same SNPs using GiAB calls in each of the three samples studied as the gold-standard. Results based on 150X sequencing for GBS are shown across variant types, technologies, and samples from different populations. Precision and sensitivity for the SNP panel matched or exceeded those in arrays, all of which were greater than 99%. Additionally, the genotyping panel allowed us to identify insertions and deletions at rates of over 90% precision and over 88% sensitivity.
