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FREE WEBINAR
High-Throughput Antibody Discovery Targeting Cell Surface Receptors
Learn how we use high-throughput iQue flow cytometry to make more informed decisions during antibody screening.
HIGH-THROUGHPUT ANTIBODY SCREENING
Abveris provides high-throughput antibody screening services to discover, characterize, and deliver optimal monoclonal antibodies.
We go beyond testing for antibody specificity using our high-throughput technology platforms. We test delivered antibodies for desired binding kinetics, epitope specificity, on-cell cross-reactivity, and functional binding profiles.
INTELLICYT IQUE FLOW CYTOMETRY
With our iQue Screener PLUS flow cytometer we screen antibodies for on-cell binding to identify massive panels of antigen-specific antibodies for further interrogation.
Advantages of the IntelliCyt iQue PLUS
The iQue achieves faster assay throughput than traditional flow cytometers by sampling only microliters from each well and delivering an air-gap-delimited flow of samples to the detectors.
The iQue Screener PLUS converts the traditional low throughput, time-consuming flow cytometry approach into a high throughput antibody screening process.
The end result is a data-rich snapshot of the molecular events occurring in each well that can take less than five minutes for a 96-well plate.
QUESTIONS WE ANSWER WITH IQUE:
- on-cell binding
- affinity (apparent KD)
- functional antibodies
- species cross-reactivity
What are Multiplexed Gene Fragments?
Application Note: How the Baker Lab used Multiplexed Gene Fragments and AI guided sequence design to discover novel antibody binders
See how the researchers were able to computationally design an entire VHH screening library de novo, and directly synthesize every candidate for experimental validation using Twist’s Multiplexed Gene Fragments.
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Blog: How massively parallel reporter assays with Multiplexed Gene Fragments are leading to the discovery of novel effector sequences
Read about new research from Harvard University into the control of cellular expression, made possible with screens that take advantage of the expanded sequence real estate in Multiplexed Gene Fragments.
READ MOREWhat will you discover with Multiplexed Gene Fragments?
With access to pooled gene-length sequences that have no limitations on sequence complexity, you can build unique screens of precisely defined sequences that would otherwise be impossible.
Are you ready to dive into unexplored sequence space?
What scientists have to say
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Twist's Multiplexed Gene Fragments push the limits of what we can synthesize, while fitting within the limits of what we can sequence. We can now explore sequence space in a targeted, deterministic fashion to build a holistic understanding of the mechanisms of protein binding. We will hopefully leverage that data to make new medicines.
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We are trying to tailor make proteins for specific design problems. Twist's 450 bp Multiplexed Gene Fragments are the ideal length for us to screen libraries of candidate proteins for ligand binding using yeast display.
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Regulatory elements have been studied deeply with traditional 120 base pair libraries, but in reality many regulatory elements are much longer than that. Using ≥ 450 base pair Multiplexed Gene Fragments from Twist we are now able to systematically screen for regulatory elements more finely tuned to drive gene expression in our specific cell type.
Results and customer experiences are specific to the institution where they were obtained and may not reflect the results achievable at other institutions
What Scientists Have to Say
Twist's Multiplexed Gene Fragments push the limits of what we can synthesize, while fitting within the limits of what we can sequence. We can now explore sequence space in a targeted, deterministic fashion to build a holistic understanding of the mechanisms of protein binding. We will hopefully leverage that data to make new medicines..
Pierce Ogden
Co-founder and CSO
Manifold Biosciences inc
The quality has been excellent, and I find that cloning with these genes is successful more often on the first time than with DNA fragments from other companies..
DR. AMANDA PORTILLO
Institute of Systems and Synthetic Biology
This is where we came to really like the online ordering portal, that tells you then and there whether Twist can make your gene. We input our sequences and Twist’s algorithms right away said “yes, why not?”. It turned out that for Twist, making these difficult sequences was easy...
DR. PHILIPPE MARLIERE
Institute of Systems and Synthetic Biology
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Application Note
Thinking about starting a project with Multiplexed Gene Fragments? Speak to a DNA expert now.
Fill out the form below to meet with an expert for help with project design, sequence optimization, order submission, and much more.
Special Offer for New Customers: 30% Discount on Initial MGF Order. This exclusive promotion is extended to new customers globally. Individuals who complete the designated online form and subsequently engage in a consultation with a sales representative will be eligible to receive a one-time discount of 30% on their first order of MGF products. This promo to only available to sequences of 250,000 or less. This offer is valid until September 30, 2025, and cannot be combined with any other promotions or discounts. Please note that certain restrictions may apply, and this offer is void where prohibited by law.
FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES
Twist Bioscience HQ
681 Gateway Blvd
South San Francisco, CA 94080
