This protocol describes a modified version of the Parse Biosciences Gene Capture protocol for full-length cDNA meant for both Illumina short read and Oxford Nanopore long read library prep and sequencing. We use Twist Biosciences exome panels to enrich for non-intronic reads for more meaningful long-read data. Each section matches the original protocol but with our modifications. Please see the attachment for the original Parse Biosciences protocol. The main deviations from the original Parse Biosciences protocol are 1. the use of cDNA amplification reagents instead of the amplification reagents included in the Gene Capture kit, and 2. modification of SPRI bead ratio from 1.8x to 0.8x. We perform this protocol on cDNA generated for a subset of 13,000 barcoded cells or nuclei from the WT or WT Mega kits.