The genomic landscape of relapsed infant and childhood KMT2A-rearranged acute leukemia

Nature communications, Oct 2025 | 16 (1), 8964

DOI: 10.1038/s41467-025-64190-8

The genomic landscape of relapsed infant and childhood KMT2A-rearranged acute leukemia

Ahlgren, Louise ; Pilheden, Mattias ; Sturesson, Helena ; Song, Guangchun ; Walsh, Michael P ; Yang, Minjun ; Maillard, Maud ; Zhao, Huanbin ; Cheng, Zhongshan ; Singh, Varsha ; Castor, Anders ; Pronk, Cornelis Jan ; Marquart, Hanne Vibeke ; Lausen, Birgitte ; Schneider, Pauline ; Barbany, Gisela ; Pokrovskaja Tamm, Katja ; Abrahamsson, Jonas ; Lohi, Olli ; Fogelstrand, Linda ; Menendez, Pablo ; Pieters, Rob ; Zhang, Jinghui ; Lindkvist-Petersson, Karin ; Yang, Jun J ; Gruber, Tanja A ; Stam, Ronald W ; Ma, Jing ; Hagström-Andersson, Anna K

PRODUCTS USED

Variant Libraries

Read Full Article

ABSTRACT

To study the mechanisms of relapse in KMT2A-rearranged (KMT2A-r) acute lymphoblastic (ALL) and acute myeloid leukemia (AML), we performed whole-genome and exome sequencing of infants and children with relapsed ALL/AML (n = 36), and longitudinal deep-sequencing of 257 samples in 30 patients. Somatic alterations in drug-response genes, most commonly in TP53 and IKZF1 (64%), were highly enriched in early relapse ALL (79%, 9-36 months after diagnosis), but rare in very early relapse ALL (

Read Full Article

PRODUCTS USED

Variant Libraries

Genes

Oligo Pools

NGS Target Enrichment Solutions

Variant Libraries

Synthetic Controls

Antibody Discovery