Involvement of the JAK-STAT pathway in the molecular landscape of tyrosine kinase fusion-negative hypereosinophilic syndromes: A nationwide CEREO study

American journal of hematology, Apr 2024

DOI: 10.1002/ajh.27306

Involvement of the JAK-STAT pathway in the molecular landscape of tyrosine kinase fusion-negative hypereosinophilic syndromes: A nationwide CEREO study

Groh, Matthieu ; Fenwarth, Laurène ; Labro, Mathilde ; Boudry, Augustin ; Fournier, Elise ; Wemeau, Mathieu ; Marceau-Renaut, Alice ; Daltro de Oliveira, Rafael ; Abraham, Julie ; Barry, Marly ; Blanche, Philippe ; Bodard, Quentin ; Braun, Thorsten ; Chebrek, Safia ; Decamp, Matthieu ; Durel, Cécile-Audrey ; Forcade, Edouard ; Gerfaud-Valentin, Mathieu ; Golfier, Camille ; Gourguechon, Clément ; Grardel, Nathalie ; Kosmider, Olivier ; Martis, Nihal ; Melboucy Belkhir, Sarah ; Merabet, Fatiha ; Michon, Adrien ; Moreau, Stéphane ; Morice, Cécile ; Néel, Antoine ; Nicolini, Franck E ; Pascal, Laurent ; Pasquier, Florence ; Pieragostini, Andrea ; Roche-Lestienne, Catherine ; Rousselot, Philippe ; Terriou, Louis ; Thiebaut-Bertrand, Anne ; Viallard, Jean-François ; Preudhomme, Claude ; Kahn, Jean-Emmanuel ; Lefevre, Guillaume ; Duployez, Nicolas ; CEREO Collaborators,

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ABSTRACT

We investigated using a custom NGS panel of 149 genes the mutational landscape of 64 consecutive adult patients with tyrosine kinase fusion-negative hypereosinophilia (HE)/hypereosinophilic syndrome (HES) harboring features suggestive of myeloid neoplasm. At least one mutation was reported in 50/64 (78%) patients (compared to 8/44 (18%) patients with idiopathic HE/HES/HEUS used as controls; p

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