Twist Custom NGS Panels let you move beyond off-the-shelf solutions, giving you full control over what you sequence. Our proprietary design strategies, developed by expert bioinformaticians, power high-performance enrichment across DNA, RNA, and methylation applications. Target exactly what matters—with precision, flexibility, and performance built in.
Traditional Barriers with Other Panels |
Twist Solutions |
|---|---|
| Uneven coverage and GC bias leading to missed variants or dropouts | Precision probe synthesis ensures balanced coverage across GC-rich and complex regions, leading to fewer dropouts |
| Probe redundancy and off-target capture wasting reads and budget | Exon-aware, junction-spanning design captures isoforms, fusions, and hard-to-reach exons |
| Complex splicing and isoform diversity missed by rigid, pre-designed panels | Uniform, reproducible data reduces revalidation cycles and speeds time to confident results |
Get the genomic data you need with a custom DNA target enrichment panel. Utilizing innovative strategies, such as our probe shifter technology, we ensure the highest performance and precision in your custom panels.
Capture transcriptomic data with a customized RNA panel - designed to capture and enrich libraries converted to cDNA. Our team utilizes novel RNA design strategies, such as exon-aware placement, to provide you with the transcriptomic insights you need.
Capture methylation data with a custom DNA methylation panel. Twist’s novel design approach achieves high uniformity and retains the methylation pattern by printing four different probe species for each target: fully methylated, fully unmethylated, sense, and antisense probes.
Twist sales may make absurd claims about how good Twist Custom Panels are, but we have found no reason to dispute those claims. We didn’t believe it until we ran their panel ourselves. Our last run had an average uniformity of 99.5%, meaning that you can drop your average coverage right down. We’ve basically doubled the number of samples we can fit on a run.
Other companies were cutting costs and focusing more on fitting everything into one box rather than working with customers to devise custom probes that fit their highly specific research needs. Twist bucked the trend.”
Twist’s Custom Panels allowed us to focus on important, medically relevant genes instead of forcing us to work with a whole genome. The panel was concise, with a simple protocol and cost was reasonable with very good candidate variants already curated by the literature.”
* Results from customer experience are not predictive of other cases. Results in other cases may vary.
Twist sales may make absurd claims about how good Twist Custom Panels are, but we have found no reason to dispute those claims. We didn’t believe it until we ran their panel ourselves. Our last run had an average uniformity of 99.5%, meaning that you can drop your average coverage right down. We’ve basically doubled the number of samples we can fit on a run.
MARK DAVIS, Ph.D.
Scientist, Neurogenetics Unit, Department of Diagnostic Genomics PathWest Laboratory Medicine, Australia
Other companies were cutting costs and focusing more on fitting everything into one box rather than working with customers to devise custom probes that fit their highly specific research needs. Twist bucked the trend.”
LYDIA SMITH
Evolutionary Genetics Lab Manager, UC Berkeley
Twist’s Custom Panels allowed us to focus on important, medically relevant genes instead of forcing us to work with a whole genome. The panel was concise, with a simple protocol and cost was reasonable with very good candidate variants already curated by the literature.”.
RENATA PELLEGRINO
PhD Technical Director at Philadephia Research Center
* Results from customer experience are not predictive of other cases. Results in other cases may vary.
Our team of bioinformaticians helps you get the most out of your panel design. Whether you are designing a panel for the first time, tackling challenging regions, or optimizing your current design - our experts are here every step of the way.
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Senior Bioinformatic Application Scientist
Lionel holds a BSc (Honours) in Biochemistry from Royal Holloway, University of London, with a specialization in bioinformatics and genomics. His background includes extensive experience in supporting bioinformatic applications and designing panels for a wide range of uses.
At Twist Bioscience, Lionel is passionate about collaborating with customers to develop innovative genomic solutions and enhance panel design through data-driven approaches. He thrives on a diverse range of applications, from panels for rare ancient DNA samples to large-scale population projects. Outside of work, Lionel enjoys spending time in nature by running.
Bioinformatics Application Scientist Manager
Rebecca Barnard is a customer focused bioinformatics applications scientist based in the US. With a PhD in Molecular Biology and assay development expertise she brings a holistic approach to panel design. She specializes in clinical and translational projects. She also enjoys partnering on emerging technology development. Twist customers are seeking to build new and creative applications so there is always an exciting project for her to tackle.
Twist Bioscience products are for research use only and are not intended for the diagnosis, prevention, or treatment of any disease or condition. Results described are customer-specific and based on data generated by the referenced institution and should not be interpreted as indicative of performance across all users or institutions.
The standard probe length for a custom panel is 120 bp; however, we do offer custom probe lengths (80, 100, 120 bp, for example). All of the probes in a panel must be the same length.
Yes, in addition to designing panels for fusions and SNPs, Twist can also design panels for viruses, MSIs (microsatellite instabilities), structural variants, copy number variants (CNVs), and InDels (insertion/deletions).
Yes, Twist can design a custom panel for Targeted Methylation Sequencing. An application note can be found here.
Yes, Twist probes are double stranded DNA.
Twist performed a NGS quality control by sequencing the probes to ensure representation in the pool.
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681 Gateway Blvd
South San Francisco, CA 94080
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