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White Paper

The Effects of Mismatches on DNA Capture by Hybridization

Targeted next-generation sequencing (NGS) focuses the sequencing effort on specific region by capturing and enriching those regions with complementary biotinylated probes. Though many factors can influence the efficiency of such capture, a primary consideration is how well the DNA sequence of the probe matches the target (sequence complementarity), as this affects both the efficiency and selectivity of capture.